摘要
５５例慢性活动性乙型肝炎患者随机分为３组．分别为异体ＬＡＫ细胞联合ＩＬ－２治疗组，单纯ＩＬ－２治疗组；一般药物对照组。在治疗前后检测周围血Ｔ细胞亚群、ＮＫ细胞活性、乙型肝炎病毒ＤＮＡ，两对半血清ＨＢＶ标志物、肝功等项目。结果表明，单纯ＩＬ－２治疗组较对照组疗效明显，免疫功能得到一定的改善（Ｐ＜０．０５），而与异体ＬＡＫ细胞联合治疗组，效果更佳，免疫功能改善有显著性差异（Ｐ＜０．０１）。
patients with chronic active hepatitis(CAH)were randomly allocated to 3 groups.20 patients were treated with combined therapy of interleukin2(IL-2)and lymphokine activated killer cell(LAK);20 patients treated with IL-2 only:while the other 15 treated with silybin and vitamines served as controls.All the patients in study were tested for T cell subsets,NK activity,HBV DNA,HBV markers,liver function before and after treatment.The results revealed that the improvement of immunological function and HBV marker negative seroconversion of the patients treated with IL-2 showed difference compared with controls(P<0. 05);however,the improvement of immunological function and HBV markers negative seroconversion of the patients treated with IL-2 and LAK cell showed;significant difference compared with controls1P<0.01).
基金
福建省教委科技三项费资助
