摘要
目的:对帕金森病伴发抑郁的发生情况及临床特点国内外研究尚少,调查帕金森病患者伴发抑郁的发生情况及分析其临床特点。方法:采用抑郁自评量表(self-ratingdepressionscale,SDS)、汉密顿抑郁量表(Hamiltondepressionscale,HAMD)及CCMD-3抑郁诊断标准对113例帕金森病(Parkinsondisease,PD)患者进行评定及诊断,统计分析其发生情况及严重程度;并与功能性抑郁症患者对照比较其HAMD总分及各因子分。结果:在113例患者中有52例(46.0%)出现抑郁症状,其中18例(16.0%)存在中重度抑郁,34例(30.0%)存在轻度抑郁,符合抑郁诊断标准的有25例(22.1%);其临床的绝望感(自卑、自杀念头)、焦虑、睡眠障碍、认知障碍等因子分与功能性抑郁相比差异无显著性意义(P>0.05),而体质量及昼夜变化等生物学症状不明显(P<0.05)。结论:抑郁是帕金森病的一个常见并发症,具有独特的临床特点。
AIM:There are still a few studies on the incidence rate and clinical characteristics of Parkinson disease(PD) accompanied by depression.The aim of this study was to investigate the incidence rate of depression in PD,and analyze its clinical characteristics. METHODS:A total of 113 PD patients were evaluated and diagnosed by self rating depression scale(SDS),Hamilton depression scale(HAMD) and diagnostic criteria of depression in the third edition of the Chinese ClassifiCation and Diagnostic Criteria of Mental Disorders(CCMD 3).Its incidence rate and severity were analyzed statistically through comparing the total score and subscore of HAMD with patients with functional depression(control group). RESULTS:Among the 113 patients,52 cases(46.0%) had depressive symptoms,including 18 cases(16.0%) of moderate severe depression and 34 cases(30.0%) of mild depression,and 25 cases(22.1%) in accordance with the diagnostic criteria of depression.The clinical scores of despair(self abasement and suicidal thought),anxiety,sleep disorder and cognitive dysfunction in the PD patients were insignificantly different from those in patients with functional depression(P >0.05), and there were no obvious biological symptoms such as body mass and circadian changes(P< 0.05). CONCLUSION:Depression is a common complication of PD,and it has some special clinical features.
出处
《中国临床康复》
CSCD
2004年第28期6038-6039,共2页
Chinese Journal of Clinical Rehabilitation
