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小剂量多巴酚丁胺超声负荷检测存活心肌及PCI前后二维观察室壁运动异常变化的临床研究

Clinical research in detecting viable myocardium by low dose dobutamine stress echocardiography and observing the change of wall motion by two-dimensional echocardiography before and after percutaneous coronary intervention
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摘要 目的 :评估小剂量多巴酚丁胺超声负荷 (LDDSE)检测存活心肌价值及通过经皮冠脉介入治疗术 (PCI)术后 2周二维超声室壁运动异常变化 ,探讨其观察室壁运动变化的准确性。方法 :18例冠心病患者均行PCI。术前 1周内 ,行LDDSE检查 ,并于术后 2周及 3月复查二维超声。结果 :随着Dob剂量增加 ,检测存活心肌敏感性、准确性增高 (P <0 0 5 ) ,特异性两者无明显变化。PCI(3M)二维超声检测有存活节段 113个 ,坏死节段 15个 ;其中术后 3月评定为存活心肌的 113个节段中 ,有 10个节段在术后 2周被判为坏死节段。PCI(2W)二维超声检测有存活节段 10 6个 ,坏死节段 2 2个。结论 :LDDSE检测存活心肌有较高的价值 ,Dob 10 μg检测存活心肌较Dob 5 μg更敏感、更准确。PCI(2W) 2 DE可以较准确地反映术前术后室壁运动变化。故在一定程度土 ,PCI(2W ) 2 DE可以作为评估存活心肌的标准。 Objective:To assess the value in detecting the viable myocardium by low dose dobutamine stress echocardiography.To detect the accuracy in observing the change of wall motion by two-dimensional echocardiography (2-DE) before and after percutaneous coronary intervention (2W).Methods:18 patients with coronary artery disease (CAD) were all performed low dose dobutamine stress echocardiography (LDDSE) before PCI and checked 2-DE after PCI (2W), PCI(3M).The value in detecting viable myocardium was compared between LDDSE and PCI (2W).Results:With the increase of dose infusion,the sensitivity, accuracy in detecting viable myocardium by Dob 10μg were higher than those of Dob 5μg (P<0.05). However, the specificity in detecting viable myocardium had no significantly difference between Dob 5μg and Dob 10μg. 113 segments which included 10 non-viable segments confirmed by PCI (2W) 2-DE and 15 non-viable segments were identifying by PCI(3M) 2-DE. 106 viable segments and 22 non-viable segments were confirmed by PCI (2W) 2-DE.Conclusion:There were higher vulues in detecting the viable myocardium by LDDSE and the sensitivity,accuracy by Dob 10μg were more high than those of Dob 5μg. To the extent, PCI (2W) 2-DE could be regarded as the standard of detecting viable myocardium because the change of wall motion pre and post-operation was able to be reflected by PCI (2W) 2-DE.
出处 《医学影像学杂志》 2004年第9期725-727,共3页 Journal of Medical Imaging
关键词 小剂量多巴酚丁胺 超声心动图 冠状动脉疾病 经皮冠脉介入治疗术 存活心肌 Low dose dobutamine Echocardiography Coronary artery disease Percutaneous coronary intervention Viable myocardium
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