摘要
目的 探讨亚低温治疗对脑外伤患者急性期脑脊液NO含量变化的影响及其意义。方法 42例各种颅脑损伤患者 分为亚低温治疗组24例,常规治疗组18例,Griess法测定受伤1、 3、7d脑脊液中NO含量变化。结果 亚低温组NO峰值(9.95± 4.01)μmol/L,明显低于常规组的(13.26±5.27)μmol/L;亚低温 组NO含量于第1d达到高峰,第3d降低并明显低于常规组,第7d 降至基本正常;常规治疗组NO含量在受伤第1d开始升高,第3d 达到高峰后开始下降,至第7d仍高于正常对照组。结论 亚低温能够降低脑外伤急性期脑脊液NO含量,亚低温抑制颅脑损伤后 NO的过量生成是其脑保护机制之一,这对探索颅脑损伤新的治疗途径具有重要意义。
Objective To investigate the influence and its significance of nitric oxide (NO) following brain injury at acute stage.Methods 42 patients were divided into mild hypothermia group (24 cases) and normothemia group (18 cases) . The value of NO was determined with Griess reagent in cerebroepina] fluid on poet - trauma K 3 and 7days.Results The peak value was lower in mild hypothermia group (9.95±4.01) μmol/L than in normothermia group (13.26±5.27) μmol/L. The contents of NO in mild hypothermia group increased to peak value on the first day, decreased than normothermia group on the third day, and got to normal on the seventh day. The value of NO in normothermia group increased on the first day, came up to peak on the third day, thereafter decreased, the value of the seventh day was also higher than control group. Conclusion Mild hypothermia can decrease the contents of NO in patients with acute brain injury, which is one of the protective mechanisms, and has important significance in probing new therapy way for brain injury.
