摘要
目的 :探讨二期梅毒的早期诊断 ,正确治疗 ,减少误诊、误治。方法 :对经血清学检查 (USR和TPPA)确诊的 12 0例二期梅毒患者的临床特点及病程作了分析 ,并对 98例采用苄星青霉素 2 4 0万U ,分两侧肌注 ,每周 1次、共 3次 ;12例采用青霉素钠 80 0万U静滴 ,每日一次 ,共 10天 ;青霉素过敏者 10例采用红霉素 5 0 0mgqid× 15d为一个疗程。结果 :1、女性居多 ,占6 1 7%。2、临床皮疹呈斑疹型 4 8例 ,病程短 ,消退快 ,平均为 6天 :扁平湿疣 4 6例 ,掌跖部皮疹 76例 ,消退较慢 ,病程相对较长 ,平均 13天 ;呈银屑病样皮疹或脓疱样疹 18例 ,则消退最慢 ,病程相对最长 ,平均 2 2天。3、二期梅毒患者经治疗后 ,平均5 5个月 ,血清学USR转阴率为 10 0 %。结论 :根据病史、临床特点及血清学 (USR和TPPA)检查可早期诊断二期梅毒 ,减少误诊、漏诊。采用苄星青霉素治疗梅毒 ,过敏者采用红霉素 ,仍是首选有效的治疗方法。
Objective To explore early diagnosis and proper management of mesosyphilis and reduce missed cases.Methods:There were 120 cases with mesosyphilis diagnosed by treponema pallidium particle agglulination test(TPPA)and unheated serum reagin test(USR).110 cases were treated by Benzathine Penicllin 240,000u im.qw.×3w and 10 cases by Erythromycin 500mg q.i.d×15d because of anaphylaxis of penicillin.Results:1.In 120 cases there were 74(61.7%)female.2.The clinical symptom in 48 cases with syphilo-macule was disappeared about six daysafter treating and 46 cases with verruca plana and 76 cases with eruption in thenar and sole disappeared about 13 days,but the symptom of 18 cases with psoriatic rash or impetigo was disappeared about 22 days.3.After treatment USR in all of cases were negative within 5.5 months.Conclusions:Early diagnosis of mesosyphilis depends on history,clinical manifestations and serum tests(USR,TPPA)and Benzathine Penicillin or Erythromycin is effective for mesosyphilis.
出处
《皮肤病与性病》
2004年第3期53-55,共3页
Dermatology and Venereology
