摘要
目的 探讨前列腺特异性抗原 (PSA)系列在前列腺癌 (PCa)筛选诊断中的价值。方法 用酶联免疫吸附法测定 6 9例PCa和 2 5 9例良性前列腺增生 (BPH)患者的血清PSA、游离PSA/总PSA (fPSA/tPSA)、PSA速度(PSAV)、PSA密度 (PSAD)和前列腺移行带PSA密度 (PSAT)值。结果 PCa组血清PSAV、PSAD和PSAT的检测值较BPH组明显升高 (P <0 0 1) ,而PSA和fPSA/tPSA两组间无明显差异 (P >0 0 5 )。PSA切变值越高 ,诊断准确性、特异性和阳性预测值越大 ,其中以PSA >10 μg/L时准确性最高。在PCa和BPH鉴别诊断意义上 ,表现为PSAT >PSAD >PSAV >fPSA/tPSA >PSA。结论 检测PSA系列 ,特别是检测PSAT和PSAD ,较单纯检测PSA在PCa筛选诊断中有较高的准确性和特异性。
Objective To investigate the value of prostate-specific antigen (PSA) and its system (PSA system) in the screening diagnosis of prostate cancer (PCa).Methods Serum PSA in 69 cases of PCa and 259 cases of benign prostate hyperplasia (BPH) was determinated by Abbot IMX assay and the PSA system such as fPSA/tPSA, PSAV, PSAD and PSAT measured. Results The values of PSAV, PSAD and PSAT in PCa patients were significantly higher than those in BPH (P<0.01), while the values of PSA and fPSA/tPSA between PCa and BPH showed no significant difference (P>0.05). The higher the cutoff value of PSA, the more precision, specificity and positive provisional value of PCa, especially at PSA>10 _g/L. As to the precision, specificity and postive provisional value for PCa among PSA and PSA system, PSAT was the best, followed by PSAD, but PSA was the worst. Conclusion Compared to PSA, PSA system, especially PSAT and PSAD, seems to be more reliable in the screening diagnosis of PCa.
出处
《华中科技大学学报（医学版）》
CAS
CSCD
北大核心
2004年第5期609-611,共3页
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
