摘要
目的 探讨糖皮质激素在SARS患者股骨头坏死中的作用。方法 对北京某医院 111例SARS康复患者出院后 1～ 4个月间双侧髋关节进行MRI扫描 ,了解股骨头坏死情况。结果 SARS康复患者出现股骨头坏死在年龄分布和是否使用激素上无统计学差异。男女比例为 1∶2 3,女性的发病率大于男性。每日激素用量≤ 16 0mg/d ,持续时间≤ 30d组股骨头坏死率最低。结论 感染SARS病毒本身就可能是发生股骨头坏死的一个独立因素。短期使用激素且每日剂量≤ 16 0mg/d可能对股骨头坏死的发生起到保护作用。
Objective To investigate the effect of glucocorticoids on femoral head necrosis in patients with severe acute respiratory syndrome.Methods We investigated 111 patients who recovered from severe acute respiratory syndrome in some hospital in Beijing.Within 1～4 months after discharge,the 111 patients were scaned with MRI.Results There was no statistical difference in both age and whether or not administered with glucocorticoidso.The ratio to male and female was 1∶2.3, and the incidence of femoral head necrosis in female was higher than that in male.The incidence was the lowest in those who were administered with daily dosage of glucocorticoids less than 160 mg/d for less than 30 days.Conclusion Whether or not administered with glucocorticoids, SARS virus probably is an independence factor of femoral head necrosis in patients. Receiving methylprednisolone less than 160 mg/d for short term can probably prevent femoral head necrosis in the SARS patients.But the hnger dosage of glucocorticoids and longer term can lead to the higher incidence of femoral head necrosis.
出处
《中华急诊医学杂志》
CAS
CSCD
2004年第10期697-699,共3页
Chinese Journal of Emergency Medicine
