摘要
目的 :观察有机硒对高血铅孕妇干预效果。方法 :通过严格的临床质量控制 ,应用石墨炉原子吸收光谱法 ,对平均血铅在 0 .34μmo1/ L 的自愿服用早期孕妇 ,采用有机硒进行全程干预 ,测定血铅及微量元素水平。结果 :孕妇至 38周分娩前干预组血铅增加 2 1.5 % ,明显低于对照组 (6 4 .5 % ) ;锌含量增加 ,并显示 GSH- Px活性提高、 L PO含量降低 ,差异有非常显著性 (P<0 .0 1)。结论 :有机硒对怀孕期间铅增高趋势有阻遏作用 ,有增强抗氧化活性功能 ,并促进锌的贮存。
Objective:To observe effectiveness of Ebselen treatments on pregnant women women with high serum lead levels.Methods:Blood sample were collected from pregnant women and detected for serum lead lenels by atom absorption spectrum.Women with mean serum lead lenels of 0.34 μmol/L at the early pregnancy were treated with Ebselen and theit serum levels of lead zinc,GSH-PX and LPO were monitored closely for a whole period of pregnancy.Results:At 38 weeks of pregnancy,in comparison with the baseline levels the Ebselen treated group had serum lead levels increased by 21.5%,which is significantly lower than the control group that was increased by 64.5%.The level of serum zinc and activity of GSH-px were significantly increased while LPO levels were significantly lower than those in the control group.Conclusion:Ebselen ameliorates the increased lead load in pregnancy and improve serum zinc and GSH-px levels as well as anti-oxidation.Therefore Ebselen may be useful in prevention of lead toxicity in the fetus.
出处
《现代预防医学》
CAS
2004年第3期420-421,共2页
Modern Preventive Medicine
