摘要
采用聚乙二醇-硫酸铵双水相系统分离手性药物扁桃酸.研究了聚乙二醇分子量、相组成、pH值和温度对扁桃酸分离的影响.结果表明,聚乙二醇分子量对双水相分离扁桃酸的影响最大;温度对扁桃酸的分离几乎没有影响;随pH增大,扁桃酸分配系数减少.
Studies on the partition of D(-)-mandelic acid were performed in polyethylene glycol(PEG) with molecular masses of 2000, 4000, 6000, 10000, 20000-ammonium sulfate systems. The effect of various parameters such as molecular mass of PEG, phase composition, pH of the system and temperature were investigated in this work. The results indicate that the molecular mass of PEG is a key factor affecting the partitioning behaviors of D(-)-mandelic acid in the PEG-(NH4)2SO4 systems. The influence of pH on the partition shows that the partition coefficient of D(-)-mandelic acid decreases with the increase of pH value. D(-)-mandelic acid partition is only slightly influenced by the temperature. All these indicate that the aqueous two-phase is a very suitable alternative system for the separation of D(-)-mandelic acid.
出处
《福州大学学报（自然科学版）》
CAS
CSCD
2004年第5期623-626,共4页
Journal of Fuzhou University(Natural Science Edition)
基金
福建省自然科学基金资助项目(C0410006)
福建省属高等院校测试基金资助项目(福20030022)
关键词
分离
双水相
扁桃酸
聚乙二醇
partitioning
aqueous two-phase system
D(-)-mandelic acid
polyethylene glycol
