摘要
目的 :评估奥曲肽在腹腔术后粘连中的作用。方法 :选用 12 0只Wistar大鼠 ,在同一标准下刮伤其盲肠浆膜 ,制成损伤性腹腔粘连模型。将动物随机分成 6组。 1组为对照组 ,于首次剖腹术后给予生理盐水作为安慰剂 0 .5ml/12h皮下注射。 2、3组分别给予奥曲肽 0 .5ml 2 .5 μg/(kg·12h)和氢化可的松2mg/(kg·12h)皮下注射 ,应用 2周 ;a、b、c组不给予任何干预 ,而于 2周后 ,实施粘连松解术 ,术后同 1、2、3组方法分别给予生理盐水、奥曲肽和氢化可的松皮下注射 ,应用 2周。 1、2、3组和a、b、c组分别于首次剖腹术和粘连松解术后 2周观察腹腔粘连程度。结果 :同对照组相比 ,奥曲肽无论在首次开腹术后还是在粘连松解术后均能显著减轻腹腔粘连 (P <0 .0 1)。而氢化可的松只在首次术后具有预防腹膜粘连的作用。结论
Objective:To assess the effect of octreotide on postoperative intraperitoneal adhesions in rats.Methods:One hundred and twenty Wistar rats were used.In a same standard,peritoneal adhesions models were made by scraping the cecal serosa with a scalpel blade.The rats were randomly divided into six groups with group one as control group.After the first laparotomy,the rats in group 1、2 and group 3 received postoperative days 0 through 14 normal saline 0.5ml/12h as placebo or octreotide 0.5ml 2.5μg·kg^(-1)·12h^(-1) or hydrocortisone 0.5ml 2mg·kg^(-1)·12h^(-1) subcutanously respectively for two weeks.Rats in group a、b and group c received no interventions in the first two weeks.And on the 14th day after operation,Group a、b and c were performed adhesiolysis of peritoneal adhesions and group a as the control group.After the adhesiolysis of peritoneal adhesions,three groups were given placebo or octreotide or hydrocortisone respectively for 14 days as rats in group 1、2 and 3.After the first laparotomy two weeks or four weeks,The severity of adhesion formation of six groups were graded respectively.Results:Compared with control groups,octreotide reduces the adhesion not only after the first operation but also after the adhesiolysis of peritoneal adhesion.However,hydrocortisone reduces the adhesion only in the first laparotomy.Conclusion:Octreotide can prevent the formation of postoperative peritoneal adhesion.
出处
《中国现代普通外科进展》
CAS
2004年第5期294-296,共3页
Chinese Journal of Current Advances in General Surgery
关键词
奥曲肽
肠
粘连
手术后期间
Octreotide·Intestines·Adhesions·Postoperative period
