胚胎干细胞定向分化运动神经元的基因调控
Directed differentiation of embryonic stem cells into motor neurons by gene
摘要
本文着重就胚胎干细胞 (ESCs)定向诱导分化为脊髓运动神经元过程中两个重要阶段及相关基因的表达调控进行综述。运动神经元分化的基因调控研究将有利于阐明其发育和分化的模式 。
Directed differentiation of ESCs into motor neurons is reviewed with focus on the expression and function of implicated genes in an attempt to understand the development of motor neurons.
基金
国家自然科学基金资助项目 (3 0 1710 68)
参考文献30
-
1Varela-Echavarria A, Pfaff SL, Guthrie S. Differential expression of LIM homeobox genes among motor neuron subpopulations in the developing chick brain stem [ J ]. Mol Cell Neurosci, 1996, 8 ( 4 ):242-257. 被引量：1
-
2Wichterle H, Lieberam I, Porter JA, et al. Directed differentiation of embryonic stem cell into motor neurons [ J ]. Cell, 2002,110:385-397. 被引量：1
-
3Briscoe J, Ericson J. Specification of neuronal fates in the ventral neural tube[J]. Curr Opin Neurobiol,2001,77 :43-49. 被引量：1
-
4Liu JP, Laufer E, Jessell TM. Assigning the positional identity of spinal motor neurons:rostrocaudal pattering of Hox-c expression by FGFs, Gdfl 1 and retinoids[ J ]. Neuron, 2001,32:997-1012. 被引量：1
-
5Dasen JS, Liu JP, Jessell TM. Motor neuron columnar fate imposed by sequential phases of Hox-c activity [ J ]. Nature, 2003,425:926-933. 被引量：1
-
6Pattyn A, Vallstedt A, Dias JM, et al. Complementary roles for Nkx6 and Nkx2 class proteins in the establishment of motoneuron identity in the hindbrain [ J ]. Development, 2003,130 ( 17 ):4149-4159. 被引量：1
-
7Takebayashi H, Nabeshima Y, Yoshida S, et al. The basic helixloop-helix factor olig2 is essential for the development of motoneuron and oligodendrocyte lineages[ J]. Curr Biol, 2002, 12 ( 13 ):1157-1163. 被引量：1
-
8Lee SK, Pfaff SL. Synchronization of neurogenesis and motor neuron specification by direct coupling of bHLH and homeodomain transcription factors [ J ]. Neuron, 2003,38 ( 5 ): 731-745. 被引量：1
-
9Muhr J, Andersson E, Persson M, et al. Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neutal tube [J]. Cell,2001,104:861-873. 被引量：1
-
10Pierani A,Moran-Rivard L,Sunshine MJ ,et al. Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx 1 [ J ]. Neuron, 2001,29:367-384. 被引量：1
-
1李小芳,霍丽丽.浅谈中老年前列腺增生的预防[J].山西预防医学杂志,2002,11(2):229-229.
-
2贾赤宇.烧伤后不同时期创面组织内生长因子与创面愈合及疤痕防治的基因调控研究[J].美中国际创伤杂志,2003,2(1):31-32.
-
3时红娟,于海娜.儿童慢性肾功能衰竭的透析治疗[J].医学美学美容（中旬刊）,2015,24(2):615-615.
-
4王强.微创治疗急性重症胰腺炎的研究进展[J].中外医学研究,2009,7(11):53-54. 被引量：1
-
5于志国,宋科官.骨形态发生蛋白2在软骨诱导方面的应用进展[J].医学综述,2013,19(4):621-623.
-
6唐余金(综述),吕小平(审校).重症急性胰腺炎内镜介入治疗进展[J].微创医学,2006,1(3X):207-210. 被引量：4
-
7姜晶,綦翠丽,董青.手术室护士对患者麻醉苏醒期的护理体会[J].中国现代药物应用,2015,9(16):171-172. 被引量：1
-
8陈瑞香,金肖青.骨量减少人群脆性骨折风险及其评估技术研究[J].浙江中西医结合杂志,2016,26(4):398-402.
-
9刘晓东,冯伟,邓廉夫,蔡体栋.活化T细胞核因子家族与破骨细胞发育和分化[J].国外医学（骨科学分册）,2005,26(3):182-183.
-
10胡永兰,陈金媛,田锦秀.心脏外科术后康复训练疗效评价(附42例临床观察报告)[J].中国康复医学杂志,1993,8(1):37-39.
