摘要
目的 :通过实验观察马兜铃科中药寻骨风水煎剂引起的肾损害及与剂量之间的关系。方法 :将Wistar大鼠随机分成 4组 :(1 )寻骨风低剂量组 :给予寻骨风水煎剂 2 .7g·kg-1 ·d-1 ;(2 )寻骨风中剂量组给予寻骨风水煎剂1 3.5 g·kg-1 ·d-1 ;(3)寻骨风高剂量组 :给予寻骨风水煎剂 2 7g·kg-1 ·d-1 ;(4 )对照组 :给予蒸馏水。均灌胃给药 ,共3个月。各组第 1、2、3月末分别采血、留尿 ,做肾功能检测及尿蛋白、尿潜血、尿糖定性检测。结果 :高剂量组第 1月末即尿蛋白阳性率增加 (P >0 .0 5 ) ,各组BUN、Scr及UA未见明显升高。肾病理检查可见寻骨风中剂量组及高剂量组不同程度肾小管 -间质损伤 ,以寻骨风高剂量组为重。结论 :大剂量寻骨风水煎剂可引起大鼠尿蛋白增加 ,肾小管 -间质损伤。
Objective:To investigate correlation between the dosage of Aristolochia mollissima Hance and renal injury.Methods:Wistar rats were divided into four groups:(1)Low dosage group:2.7 g·kg -1 ·d -1 of Aristolochia mollissima Hance decoction given to rats for three months;(2)Moderate dosage group:13.5 g·kg -1 ·d -1 of Aristolochia mollissima Hance decoction was given for three months;(3)High dosage group:27 g·kg -1 ·d -1 of Aristolochia mollissima Hance decoction was given for three months; (4)Control group: water was given for three months. Renal function and urinary protein excretion were examined every month for three months. Pathological changes were examined by the end of third month.Results:Urinary protein excretion increased in the high dosage group,but there were no statistical differences in renal function. The renal pathologic examination showed slight tubular-interstitial injury in moderate dosage group, mild to moderate injury in moderate dosage group and mild to moderate injury in high dosage group.Conclusion:High dosage of Aristolochia mollissima Hance may induce renal tubular-interstitial injury.
出处
《中国中西医结合肾病杂志》
2004年第9期507-509,共3页
Chinese Journal of Integrated Traditional and Western Nephrology
基金
黑龙江省人事厅博士后科研启动基金资助项目 (No .LRB -ky0 10 5 9)
