摘要
最近在甘肃进行的研究表明 ,居室内氡浓度的增加会导致肺癌危险度增高 ,这与以往进行的汇总分析和其他居室研究的综合分析结果一致 (王作元 ,等 .美国流行病学杂志 ,2 0 0 2 .1 5 5 :5 5 4)。室内氡浓度产生的剂量用过去 3 0年中的氡浓度表示 ,这在暴露量方面会有一定程度的不确定度 ,有可能降低对肺癌危险度的估计。我们进行了一项为期三年涉及 5 5户居民的辅助研究 ,目的是找出室内氡水平时间、空间变化模型 ,并对氡致肺癌危险度的估计进行调整。氡浓度的时间变化是产生不确定度的最大来源 ,对室内氡进行连续几年的观测以找出其变化原因和规律很有必要。不确定度的调整使肺癌附加比值比 (excessoddsratio)估算值增加 5 0 %～ 1 0 0 %。说明用类似剂量方法进行的室内氡研究也可能低估了氡致肺癌效应。
Recent study in Gansu Province reported an increasing risk of lung cancer with increasing residential radon concentration,which is consistent with previous pooled analyses and with meta-analyses of other residential studies(Wang Z Y, et al.Am.J.Epidemiol.,2002.155:554).Dosimetry substitutes current radon measurements in dwelling houses for its concentrations of previous 30 years with resulted in uncertainties in exposure and possibly reduced estimates of disease risk.The 3-year substudy was conducted in 55 houses in order to model temporal and spatial variability in radon levels and adjust estimates of radon risk.Temporal variation represented the single largest source of uncertainty,it is suggested multi-year measurements to assess this variation;However,substantial residual variation remained unexplained.The uncertainty adjustment increased estimates of the excess odds ratio by 50～100 percent,suggesting that residential radon studies using similar dosimetry may also underestimate radon effects.These results have important significance to risk assessment. (
出处
《辐射防护》
CAS
CSCD
北大核心
2004年第5期279-288,共10页
Radiation Protection
