摘要
目的 初步探讨芳香化酶抑制剂 -兰他隆治疗复发性子宫内膜癌的临床效果。方法 对 3例手术后复发、化疗及放疗后病情未控的子宫内膜癌患者 ,应用兰他隆 2 5 0mg ,肌肉注射 ,每 2周 1次 ,8周为一疗程 ,治疗期间每周化验外周血象、肝肾功能 ,疗程结束后 2周评判疗效。结果 1例病情完全缓解 ,1例病情稳定 ,1例病情进展。 3例患者均未出现与用药有关的毒副作用。结论 芳香化酶抑制剂兰他隆治疗复发性子宫内膜癌有一定的临床效果 。
Objective To evaluate the outcome of relapsed endometrial carcinoma treated with aromatase inhibitor Lantaron. Methods Three women with postoperative relapsed endometrial carcinoma, who were with uncontrolled disease after chemotherapy or/and radiotherapy, treated with Lantaron at 250 mg/2 weeks, 8 weeks/course, muscular injection. Peripheral blood cells were counted and the function of liver and kidney were checked every week during the treatment. The clinical outcome was evaluated at 2 weeks after the course finished. Results One of the 3 cases was complete response, one was stable disease and the other one was disease progression. No obvious toxicity was found in this study. Conclusions Aromatase inhibitor, Lantaron can be a selvage drug to treat refractory endometrial carcinoma, without severe side effect.
出处
《中国妇产科临床杂志》
2004年第3期185-186,共2页
Chinese Journal of Clinical Obstetrics and Gynecology
基金
首都医学发展科研基金 (首都ZD199911)资助
