摘要
目的 :探讨对蒽环类药物耐药乳腺癌的有效化疗方案。方法 :对 2 3例蒽环类药物治疗过的转移性乳腺癌给予国产去甲长春花碱 (盖诺 ,NVB)加顺铂 (DDP)化疗。结果 :2 3例患者总有效率 5 6 5 % ,其中单发转移病灶有效率 6 6 7% ,多发转移灶有效率 5 0 0 %。肺转移灶有效率 6 6 7% ,胸壁转移灶有效率 5 0 0 % ,对侧乳腺转移灶有效率 33 3% ,淋巴结、胸膜、骨、肝转移灶有效率分别是 5 6 5 %、4 0 0 %、11 0 %、0 ,心包 10 0 %。剂量限制性毒性是骨髓抑制。结论
Objective To investigate the effective chemotheraputic regimen for breast cancer resistant to anthracycline.Metheds The combined chemotherapy consisting of Vinblastine (NVB) and Cisplatin(DDP) was performed on 23 cases of metastatic breast cancer patients who had been treated with anthracycline.Results An overall response rate of this group was 56.5%(11 achieved partial response).The response rate of single metastatic breast cancer was 66.7%,and the response rate of multiple metastatic breast cancer was 50.0%.Metastatic targets were lung 66.7%,chest wall 50.0%,contralateral breast 33.3%,lymph nodes 56.5%,pleurae 40.0%,bone 11.0%,liver 0%,pericardia 100%,respectively.The dose-limiting toxicity was neutropenia (grade Ⅲ and Ⅳ were 33.3% of patients).Conclusions The result showes the combination of NVB and DDP is an effective regimen as second-line treatment for metastatic breast cancer patients resistant to anthracycline.
出处
《肿瘤防治杂志》
2003年第12期1284-1286,共3页
China Journal of Cancer Prevention and Treatment
关键词
乳腺肿瘤
药物疗法
长春碱
投药和剂量
顺铂
投药和剂量
抗生素类
蒽环
抗药性
肿瘤
breast neoplasms/drug therapy
vinblastine/administration & dosage
cisplatin/administration & dosage
antibiotics,anthracycline
drug resistance,neoplasm
