摘要
目的 探讨扩张型心肌病 (DCM)患者血清生长激素 (GH)水平的变化规律及其意义。方法 采用放射免疫分析法测定 4 3例DCM患者和 4 0例健康对照组 2 4小时内 3个时点 (8:0 0Am、4 :0 0Pm、12 :0 0Pm)的血清GH浓度 ,同时用超声心动图测定左室射血分数 (LVEF)。结果 LVEF≤ 0 .2 0的DCM亚组平均GH水平明显低于LVEF >0 .2 0的DCM亚组和对照组 (P <0 .0 5 )。DCM组平均GH水平与LVEF呈正相关 (r =0 .5 15 ,P =0 .0 0 2 )。DCM患者的平均血清GH随充血性心力衰竭 (CHF)的加重而降低。心功能Ⅳ级的DCM患者平均GH水平明显低于对照组 (P =0 .0 32 )。结论 血清GH水平可能是反映CHF严重程度的敏感指标之一 ,DCM患者补充一定量的GH可能具有改善心功能的作用。
Objective To investigate the change of serum level of growth hormone(GH) in patients with dilated cardiomyopathy(DCM) and its significance.Methods Serum level of GH was measured with radioimmunoassay in 43 patients with DCM and 40 healthy control subjects at 8 Am,4 Pm,12 Pm within 24 hours.Left ventricular ejection fraction(LVEF) was obtained by echocardiography.Results In the patients with LVEF≤ 0.20 ,the mean GH was significantly reduced compared with that of the subgroup of patients with DCM and their LVEF> 0.20 ,and to healthy control subjects.Between the mean GH concentration and LVEF value in patients with DCM,significant positive correlation was found (r= 0.515 ,P= 0.002 ).The decrease of serum level of mean GH in patients with DCM closely correlated with the severity of symptoms of congestive heart failure (CHF).Serum level of mean GH in patients with DCM in New York Heart Association(NYHA) class Ⅳ was significantly reduced compared with that of healthy control subjects(P= 0.032 ).Conclusion Serum level of GH was one of sensitive targets in reflecting the severity of CHF.In the patients with DCM,supplement of appropriate GH may have a role in improving cardiac function.
出处
《临床荟萃》
CAS
北大核心
2004年第19期1087-1089,共3页
Clinical Focus
基金
广西壮族自治区卫生厅课题基金资助 (Z2 0 0 0 35)
关键词
心肌病
充血性
生长激素
每搏输出量
cardiomyopathy,congestive
growth hormone
stroke volume
