摘要
目的 研究鼠源性抗人白细胞介素 2受体单克隆抗体WuTac的功能和药效作用。方法 采用间接免疫荧光法检测WuTac对白细胞介素 2的阻断作用 ;采用同位素法检测WuTac对活化的T细胞增殖的影响 ,并且通过移植物抗宿主的反应 (GVHR)对WuTac体内的药效作用进行评价。结果 WuTac可以明显地抑制人白细胞介素 2的作用 ,并且可以明显地抑制移植物抗宿主的反应。结论 WuTac可以作为一种较为理想的免疫抑制剂 。
Objective To study the function and pharmacodynamics of therapeutical murine anti-human monoclonal antibody WuTac.Methods Study the inhibiting effect of WuTac on IL-2 activity by indirect immunofluorescence, the influence of WuTac on proliferation of activated T cell by isotope method, and the in vivo pharmacodynamics of WuTac by graft versus host reaction (GVHR).Results WuTac significantly inhibited IL-2 activity, T cell proliferation and GVHR.Conclusion WuTac may be used as an ideal immunmodepressant for prevention and treatment of GVHR in bone marrow transplantation and acute rejection reaction in organ transplantation.
出处
《中国生物制品学杂志》
CAS
CSCD
2004年第5期294-296,共3页
Chinese Journal of Biologicals
