摘要
【目的】 观察单纯性肥胖儿童瘦素水平变化 ,探讨其与血脂代谢的关系。 【方法】 单纯性肥胖儿童及对照组各 3 0例。两组儿童均测量身高、体重 ,计算体质指数。采用放射免疫分析法检测两组儿童血清瘦素 (lep tin)、酶比色法测血甘油三酯 (triglyceride ,TG)、胆固醇 (cholesterol,Tch) ,用磷钨酸 镁法测血高密度脂蛋白 (highdensi tylipoprotein ,HDL C) ,通过公式LDL =|TG/ 5 +HDL TG |计算血低密度脂蛋白 (lowdensitylipoprotein ,LDL C)等血脂指标。对两组儿童的瘦素、血脂分别进行t检验 ,并进行相关性分析。 【结果】 肥胖组儿童的瘦素、血脂水平明显升高 ,差异有显著性 (P <0 .0 5 )。相关性分析显示肥胖组瘦素与体块指数、体表面积 ,血脂存在正相关关系。 【结论】 肥胖组儿童存在高瘦素血症、瘦素抵抗现象 ;瘦素抵抗可能间接地在心血管系统疾病、血脂紊乱中有一定作用。
Objective To investigate the levels of leptin and their effects on the levels of blood lipid in the simple obesity children. 30 simple obesity children and 30 normal weight children were studied. Serum leptin was measured by radioimmunoassay, blood triglyceride(TG) and cholesterol (Tch) were measured by GPO-PAP method, high density lipoprotein (HDL) was measured by deposition method and low density lipoprotein (LDL) was calculated by the formula LDL=｜TG/5+HDL-TG｜. Body mass index (BMI) was calculated by the formula BMI=weight (kg)/(body length)(m) 2. The levels of serum leptin in obese group were dramatically higher than those in control group (P<0.05). The relationships between blood lipid and the levels of serum leptin in obese group were significantly higher than those in control group (P<0.05). In two groups, the relationships between leptin concentration and BMI,the correlations was higher between leptin concentration and TG concentration. [Conclusions] Simple obesity children have higher levels of serum leptin and leptin resistance (LR). LR likely plays the inderect roles on dyslipoidosis.
出处
《中国儿童保健杂志》
CAS
2004年第4期307-309,共3页
Chinese Journal of Child Health Care
关键词
单纯性肥胖
瘦素抵抗
血脂
儿童
simple obesity
leptin resistance
blood lipid
children
