摘要
本文应用了白细胞粘附抑制试验和IL_2活性检测试验分别探讨了不同脏器来源的抗大肠杆菌iRNA在肌体内诱导的细胞免疫活性的异同,正常小鼠分别经肝、脾iRNA致敏后,取腹腔渗出细胞(PEC)测其粘附抑制情况和取脾测其产生IL_2的活性。结果表明:脾-iRNA能特异地诱导正常小鼠PEC对其相应抗原出现显著的粘附抑制,肝—iRNA无此活性;肝—iRNA和牌—iRNA都能特异地诱导正常小鼠脾细胞在其相应抗原刺激下释放IL_2,二者活性无显著差异。本文提示,肝—iRNA和脾—iRNA都具有在动物体内特异地诱导细胞免疫的的活性,但二者间存在着差异。
The cellular immune activities of anti-E. coli Spleen-iRNA (SiRNA) and Liver-iRNA were studied with the tests of leucocyte adhernece inhibition (LAI) and the detection of IL-2 activity. The results showed that the S-iRNA can specifically induce the mouse PEC to inhibit their own adherence response to corresponding Ag, whereas L-i-RNA can't; and that both S-iRNA and L-iRNA can induce the mouse splenocytes to pr-oducc IL-2 under the stimulation of the corresponding Ag and there is no statistic difference in activity between them. It was suggested that both S-iRNA and L-RNA can transfer the cellular immune activities to normal mice but there is difference in immune activity between them.
出处
《免疫学杂志》
CAS
CSCD
北大核心
1989年第2期29-32,共4页
Immunological Journal
关键词
细胞免疫活性
IRNA
肝
脾
Cellular Immunity,Spleen-IRNA,Liver-iRNA,IL-2,Leucocyte adherence inhibition
