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琥珀酸罗哌卡因与进口盐酸罗哌卡因注射液药效学比较研究

Comparative studies on the pharmacological effects of ropivacaine chelidoninic acid and imported hydrochloride ropivacaine
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摘要 目的 :评价国产琥珀酸罗哌卡因粉针剂及进口盐酸罗哌卡因注射液的药效学特征 ,为临床应用提供实验依据。方法 :琥珀酸罗哌卡因临床主要用于外科手术麻醉、局部麻醉等 ,我们对两药进行了 4种动物模型药效学实验研究。结果 :两药在相同剂量下的表面麻醉、浸润麻醉、传导麻醉及椎管麻醉作用相近 ,麻醉浓度和麻醉效能间呈现良好的量效关系。经统计学分析 ,两药 EC50 之间无显著差异。结论 :认为国产琥珀酸罗哌卡因可以成为进口盐酸罗哌卡因注射液理想的代用品。 Object: To evaluate the features of the pharmacological effects of ropivacaine chelidoninic acid as well as imported hydrochloride ropivacaine and provide experimental basis for clinical use. Methods: Ropivacaine chelidoninic acid is mainly used as a surgical operation anesthesia or local anesthesia. The pharmacological experiments with four types of animal models were carried out for both drugs. Results:Under the same dosages, the effects of two drugs on surface anesthesia, infiltration anesthesia, conduction anesthesia and intravertebral anesthesia were similar. There were a good relationship between the concentration and the effects. The statistic analysis showed no remarkable differences in EC50 for two drugs. Conclusion: Consequently, the imported hydrochloride ropivacaine injection may be substituted by ropivacaine chelidoninic acid.
出处 《天津药学》 2004年第4期1-3,共3页 Tianjin Pharmacy
关键词 琥珀酸罗哌卡因 盐酸罗哌卡因 药效学 ropivacaine chelidoninic acid, hydrochloride ropivacaine,pharmacodynamics
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  • 1徐叔云等主编..药理实验方法学 第2版[M].北京:人民卫生出版社,1982:1554.
  • 2柳晓泉,于峰,傅继华,葛卫红,汪小海.碱性盐酸利多卡因与盐酸利多卡因麻醉作用的比较[J].中国药科大学学报,1996,27(2):107-110. 被引量:10
  • 3施新猷主编..现代医学实验动物学[M].北京:人民军医出版社,2000:612.
  • 4周海钧 申蕴如.生物检定统计方法(第2版)[M].北京:人民卫生出版社,1988.50. 被引量:2
  • 5津田恭介 野上寿.药效的评价(1)药理实验法中医药品开发基础讲座V[M].日本:东京新宿地人书馆,1971.919-943. 被引量:1

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