摘要
观察重组人红细胞生成素 (rHuEPO)每周 1次皮下注射治疗非透析患者肾性贫血的临床疗效及副反应。方法 选择慢性肾功能衰竭并肾性贫血的非透析患者 3 0例 ,治疗组 15例 ,采用rHuEPO 60 0 0U每周 1次皮下注射 ;对照组 15例 ,采用相同产品rHuEPO 3 0 0 0U每周 2次皮下注射。治疗期间 ,监测血常规、肝肾功能、电解质、血压及各种不良反应。结果 试验组显效 7例、有效 5例、无效 2例 ;对照组显效 6例、有效 4例、无效 2例 ,治疗前后两组治疗观察指标及副反应均无统计学差异。结论 rHuEPO每周 1次注射方法与分次注射有同样治疗价值 ,且减少病人负担 。
Objective To evaluate the clinical effect of rHu EPO once a week on non-dialysis patients with uremic anemia.Methods Thirty patients were divided into 2 groups at random.Fifteen patients in treatment group accepted 6000U of rHu EPO through subcutaneous injection once a week,Fifteen patients in control group accepted 3000U of rHu EPO through subcutaneous injection 2 times every week.Blood routine,liver and kidney function,electrolyte,blood pressure and side effects were observed.Results The obvious effective,effective and ineffective cases in treatment group were 6,4 and 4 respectively,and 5,3 and 4 in control group respectively.Routine blood test,the pre-and post-treatment liver and kidney function,electrolyte,blood pressure and side effects showed no statistical difference in 2 groups.(Conclusion) Treatment of uremic anemia with rHu EPO once a week is effective,safe and available to patients.The side effect of rHu EPO is similar in 2 groups. \[
出处
《临床内科杂志》
CAS
北大核心
2004年第9期621-623,共3页
Journal of Clinical Internal Medicine
关键词
重组人红细胞生成素
肾性贫血
Recombinant human erythropoietin
Uremic anemia
