摘要
以自制的手性环二肽 [环 (D 苯丙 D 组 ) ]作为催化剂 ,以液态HCN和 3 苯氧基苯甲醛为原料催化合成(S ) α 氰基 3 苯氧基苯甲醇 ,产率为 86 % ,对映体过量值ee %为 90 ,探索了反应时间、催化剂用量对反应转化率和产品品质的影响 ,同时将S 氰醇应用于合成 (S ,S ) 氰戊菊酯、 (1R ,3R ,αS ) 溴氰菊酯、 (S ,S ) 甲氰菊酯和 (1R cis,3S ) 苯醚氰菊酯 ,它们的产率分别为 80 %、 75 %、 80 %、 75 % ,对映体过量值ee%分别为90、 75、 70、 70。
S α Substituted α cyanomethyl alcohol is prepared from 3 phenoxybenzaldehyde and hydrocyanic acid by cyclo(D Phe D His),the yield is 86% and the ee% is 90.The effects of the ratio of catalyst to 3 phenoxybenzaldehyde and reaction time have been discussed in detail.The S α cyano benzyl alcohol has been applied to synthesis (S,S) fenvalerate,(1R,3R,αS) decamethrin,(S,S) fenpropathrin and (1R cis,S) cyphenothrin,their total yields are 80%,75%,80%,75% respectively and their ee% are 90,75,70,70 respectively
出处
《农药》
CAS
北大核心
2004年第7期318-320,共3页
Agrochemicals
关键词
(S
S)-氰戊菊酯
(1R
3R
αS)-溴氰菊酯
(S
S)-甲氰菊酯
(1R-cis
3S)-苯醚氰菊酯
(S)-α-氰基-3-苯氧基苯甲醇
制备
催化剂
S,S) fenvalerate,(1R,3R,αS) decamethrin,(S,S) fenpropathrin,(1R cis,3S) cythenothrin,S α cyano benzyl alcohol,synthesis,Catalyst
