摘要
吖啶及吖啶酮类化合物具有广泛的药理活性,其中许多化合物具有明显的杀菌、抗炎、增强记忆、镇痛和抗癌等活性。如早年开发的抗癌药物山柚柑碱(Acronycine)就具有显著的抗癌作用,且抗瘤谱较广。近年来抗癌新药安吖啶(Amsacrime)在临床上用于治疗急性白血病收到疗效后,对吖啶及吖啶酮衍生物的合成及抗癌活性研究日渐增多。
Syntheses of 7, 10-diaryl-7,8,9,10,11, 12-hexahydro-benzo[C]acridin-8-ones (la-g) were achieved by reaction of 5-aryl-1, 3-cyclohexanedione, α-naphthylamine and the appropriate aromatic aldehydes in ethanol or benzene. The oxidation of compounds la-g with CrO3 in acetic acid giving 7, 10-diaryl-8, 9, 10, 11-tetrahydrobenzo[C]-acridin-8-ones (2a-g) is also reported. The structures of 14 new compounds were characterized by elementary analysis, IR, and 1H NMR spectra. The preliminary pharmacodynamic experiments show that compounds Ic, 1f, 2f possess a significant inhibition effect on the growth of KB cell.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1993年第6期806-808,共3页
Chemical Journal of Chinese Universities
关键词
苯并吖啶酮
有机合成
抗癌活性
Benzoacridinone, Organic synthesis, Anticancer activity
