摘要
以α 环柠檬醛 ( 2 )为A环合成子 ,以间甲氧基苄基氯 ( 3 )为C环合成子 ,经缩合及分子内环化反应得关键中间体 6.经1HNMR测试发现化合物 6为全顺式结构 .化合物 6经氧化得双羰基化合物 7.将 7用t BuOK/t BuOH处理后得到烯醇式结构的化合物 8.最后将异丙基通过Fridel Crafts反应一步引入得到目标产物 1.
By using α-cyclocitral (2) as the A ring synthon, and m-methoxy benzyl chloride (3) as the C ring synthon, the key intermediate 6 was obtained after the condensation and intracyclization reactions. Compound 6 was found to be an all-cis isomer through 1H NMR. The oxidation of 6 afforded the diketone 7, and the enolization of 7 in t-BuOK/t-BuOH afforded compound 8. Finally, the group of iso-propyl was introduced to compound 8 through Fridel-Crafts reaction to afford the target product 1.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2004年第8期933-936,共4页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金 (No.2 0 1 72 0 2 3 )资助项目
