摘要
背景:药物治疗是偏头痛的主要治疗方法,而对平肝通络中药治疗偏头痛的作用机制的研究较少。目的:证实平肝通络颗粒对家兔脑膜血管具有双相调节作用。设计:完全随机安慰剂及阳性药物对照,单盲实验研究。地点和对象:实验在湖南省中医药研究院动物室完成。采用家兔脑膜血管。市售家兔24只,雌雄不限,体质量2.5～3kg,由湖南省中医药研究院动物室饲养2周以上。干预:平肝通络颗粒十二指肠给药与静脉注射给药的颅通定对照,试验完成、血管管径恢复后,各再给药1次,30min后由耳缘静脉按5μg/kg注射5-羟色胺。主要观察指标:兔脑膜小血管管径值。结果:平肝通络颗粒能够扩张正常家兔脑膜小血管管径,同时明显对抗注射5-羟色胺后兔脑膜血管管径的扩张,呈现双相调节作用。结论:平肝通络颗粒治疗偏头痛有一定的药理学依据。
BACKGROUND:Pharmacotherapy is the main treatment for migraine.However,few rese arches have been reported on the mechanism of treating migraine with traditional Chinese medicine ping gan ton gluo. OBJECTIVE:To confirm the dual-adjusting effect of the ping gan tong luo granu les(PGTLG) on the meningeal small vessels in rabbits. DESIGN:A completely randomized,placebo-controlled,and single-blind experimen tal study was conducted. SETTING and PARTICIPANTS:The experiment was completed in the Laboratory Animal Room,Hunan Academy of Traditional Chinese Medicine.Rabbit meningeal vessels wer e used.Twenty-four rabbits,weighing 2.5 to 3 kg were purchased from markets wit h either gender, and kept for more than 2 weeks in the above research room. INTERVENTIONS:PGTLG was given to the duodenum,and intravenously administered t etrahydropalmatine was adopted as control.After the experiments were finished,PG TLG or control was given once more to restore vessel diameters;Thirty minutes la ter,5 μg/kg of 5-HT was injected to the ear vein. MAIN OUTCOME MEASURES:Diameters of meningeal small vessels in rabbits. RESULTS:PGTLG dilated the meningeal small vessels in normal rabbits,and restra ined the dilating of 5-TH-induced meningeal small vessels. CONCLUSION:PGTLG has a promising pharmacological effect in treating migraine.
出处
《中国临床康复》
CSCD
2004年第22期4662-4663,共2页
Chinese Journal of Clinical Rehabilitation
基金
湖南省卫生厅中医药科研基金(98009)~~
