摘要
目的 探讨影响非小细胞肺癌术后早期复发的临床病理因素 ,了解血清癌胚抗原(CEA)检测对预测非小细胞肺癌患者术后早期复发的作用。方法 对 2 0 0 0年 9月～ 2 0 0 2年 8月收治的 93例非小细胞肺癌患者行手术治疗 ,术前行血清CEA测定 ,术后随访 1年以上 ,记录第 1次复发的时间。应用Logistic回归分析观察影响非小细胞肺癌术后早期复发的临床病理因素 ,应用受试者工作特征 (ROC)曲线进行数据分析 ,比较各危险因素预测非小细胞肺癌术后早期复发的能力。结果血清CEA水平、临床分期和肿瘤分化与非小细胞肺癌术后早期复发有关。其中CEA >10 μg/L是预测非小细胞肺癌术后早期复发较好的指标 (ROC曲线下面积 :0 84 3,95 %CI :0 72 3～ 0 96 3,P =0 0 0 0 )。结论 对于可以手术切除的非小细胞肺癌患者 ,术前应行血清CEA水平测定 ,术前血清CEA >10 μg/L提示 。
Objective To explore clinical and pathological factors correlating with early recurrence of resected non small cell lung cancer (NSCLC),and to further understand the function of serum carcinoembryonic antigen (CEA) on NSCLC. Methods 93 patients of NSCLC were selected. All of them received resection and were followed up for more than one year. The first time of recurrence was recorded. Logistic univariate and multivariable analysis were used to find the factors that affect the early recurrence of NSLSC, including age, sex, serum CEA level, tumor size, tumor location, tumor differentiation, histological type and clinical staging, and the ability of factors predicting the recurrence were compared by receiver operating characteristic (ROC) curve. Results Of all the clinical and pathological factors that are correlated with early recurrence of NSCLC, the serum carcinoembryonic antigen(CEA) value, clinical staging, and tumor difference are of statistical significance. The preoperative serum CEA value is the most valuable factor to predict early recurrence of NSCLC(ROC area: 0 843, 95% CI :0 723～0 963, P =0 000). When preoperative serum CEA value >10 μg/L, patients of NSCLC will have an early recurrence rate of 88%; and when preoperative serum CEA value ≤10 μg/L, the probability of no early recurrence is 92%. Conclusion For the patients with respectable NSCLC, it is very important to know the precise clinical stage and pathological difference, and so is the preoperative serum CEA value. When preoperative serum CEA value>10 μg/L, even if the lesion is of early stage and well differenced, the general situation of patients should be carefully examined for the prompt and accurate treatment to them and close follow up is needed to treat these patients.
出处
《中华外科杂志》
CAS
CSCD
北大核心
2004年第13期817-819,共3页
Chinese Journal of Surgery
关键词
血清癌胚抗原
预测
非小细胞肺癌
术后
早期复发
Cancer,non-small cell lung
Neoplasm recurrence,local
Carcinoembryonic antigen
Neoplasm stage
Tumor difference
ROC curve
