摘要
抗体偶联药物与肿瘤相关靶点结合有特异性,对肿瘤细胞有选择性杀伤作用,临床上已开始用于治疗肿瘤。综述了抗体与抗癌药物偶联物的偶联方式和药物释放的靶向机制,以及采用大分子聚合物做载体(如葡聚糖、人血清白蛋白、聚N-2羟丙甲基丙烯酰胺)的抗体偶联药物的研究现状。
Antibody-immunoconjugated agents show specific binding property to tumor related targets and exhibit selective cytotoxicity to target cancer cells. Now, some of these agents have been used in clinical therapy. In this paper, the conjugated patterns and the mechanism for targeting release as well as research advances in using macromolecule as carrier in these drugs were reviewed.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2004年第6期488-491,共4页
Chinese Journal of New Drugs
关键词
抗体
免疫偶联物
抗癌药物
大分子
antibody
immunoconjugates
anti-cancer drugs
macromolecules
