摘要
在放射性裂变产物中,观察到小剂量不同辐射体核素^(147)Pm和^(134)Cs内辐照对骨髓和胸腺细胞的刺激增殖作用。^(147)Pm的体内滞留方程,用最小二乘法拟合为:R(t)=0.199e^(-0.1452t)+0.812e^(-0.0008t),包括快、慢两个不同的滞留半减期,其中快组分T_1=4.77d,而慢组分T_2=866.3d。^(134)Cs的体内滞留方程为:R(t)=18.04 e^(-9.3175t)+45.13 e^(-0.0423t),其快组分T_1=0.07d,慢组分T_2=16.14d。当大鼠静脉摄入^(147)Pm 0.185—0.74 kBq/g或^(134)Cs 0.37—1.85kBq/g后,可使骨髓细胞和胸腺细胞的~3H-TdR掺入率呈显著增升,表明其DNA合成能力增高,有刺激骨髓与胸腺细胞增殖作用。
In this article the dynamic tetention of fission products ^(134)Cs and^(147)Pm as well as the proliferation ability on cells of bone marrow and thymus ofrats were investigated. The retention equation of ^(134)C_S was well described. by a two-exponential function, that is=R(t)=18.04^(-9.3175t)+ 45.13 e^(-0.0423t) There are tworetention components, fast and slow. The effective biological T_(1/2) were 0.07 and16.14 days respectively. While the retention equation of ^(147)Pm is: R(t)=0.199e^(-.1452t)+0 .812e^(0.0008t) Where the fast component T_1was 4.77 d: and the slow com-poment T_2 was 866.3 d. Results show that the proliferation of bone marrow cells andthymus cells were excited with a low dose internal irradiation of ^(134)Cs from 0.37to 1.85 kBq/g and of ^(147)Pm from 0.185 to 0.74 kBq/g. It showed that a stimulatoryresporse of cell proliferation induced by low doses of ^(134)Cs and ^(147)Pm has been observed.
出处
《辐射研究与辐射工艺学报》
CAS
CSCD
北大核心
1993年第3期172-175,171,共5页
Journal of Radiation Research and Radiation Processing
基金
国家自然科学基金资助课题
关键词
胸腺
骨髓细胞
小剂量辐照
内辐照
Low dose
Interna Iradiation
^(147)Pm
^(134)Cs
Bone marrow cells
Thymus cells. Stimulatory effect
