摘要
用2-硫代-3-正丁基-5-苯基亚甲基-4-咪唑啉二酮(1)的S-烷基化反应合成了新型2-烷硫基-3-正丁基-5-苯基亚甲基-4H-咪唑啉-4-酮衍生物(2)。对影响S-烷基化反应的条件进行了优化,优化条件如下:2-硫代-4-咪唑啉二酮5mmol、卤代烷6mmol和无水碳酸钾8mmol;反应温度50°C或室温;反应时间2～3h。优化条件下2a～2e的收率为43%～81%。探讨了所合成化合物的波谱性质,其结构经元素分析、IR、1HNMR和MS确证。
The novel 2-alkylthio-3-(n-butyl)-5-phenylmethylidene-4H-imidazolin-4ones (2) were synthesized by S-alkylation reaction of 2-thio-3-(n-butyl)-5-phenylmethylidyne-4-imidazolidinone (1).The reaction conditions of S-alkylation were studied. The optimum conditions were: 2-thio-4-imidazolidinone, 5 mmol; alkyl halides, 6 mmol; potassium carbonate, 8 mmol; reaction temperature (50°C) or room temperature; reaction time, 2～3 h. Under the optimum conditions, the yields of 2a～2e were 43%～81%. The synthesized compounds were identified, and their structures were confirmed by elemental analysis, IR, ~1H NMR and MS.
出处
《化学世界》
CAS
CSCD
北大核心
2004年第8期424-427,共4页
Chemical World
基金
国家自然科学基金(20102001)
湖北省教育厅自然科学基金(2003A002)资助项目
