摘要
目的 探讨层黏连蛋白(LM)和Ⅳ型胶原在前列腺不同疾病中的表达及意义。方法 将100例诊断明确的前列腺标本分为5组,即正常组、良性增生组(BPH)、高级别上皮内瘤组(HPIN)、偶发癌组和前列腺癌组,每组20例。应用SP法检测LM和Ⅳ型胶原在5组标本中的表达。结果 LM和Ⅳ型胶原的表达基本一致,在正常组、BPH及大部分HPIN组织中呈棕黄色连续环线状包绕前列腺腺泡及导管外周,且分布均匀;但在部分HPIN组织中排列不规则、分布不均匀或紊乱;在偶发癌病灶区有片状缺失、间断或分布杂乱;在前列腺癌组织中均呈大片状或多灶性缺失,或杂乱排列。结论 LM和Ⅳ型胶原在前列腺不同疾病中的表达有差异,偶发癌和前列腺癌的基底膜损伤明显。提示LM和Ⅳ型胶原的表达不仅有助于预测HPIN的癌变潜能,也对前列腺良、恶性疾病的鉴别有帮助。
Objective To explore the expression and significance of laminin (LM) and collagen Ⅳ (CⅣ) in all kinds of prostate tissue. Methods 100 specimens of prostate were divided into 5 groups: normal prostate (NP), benign prostate hyperplasia (BPH), high grade prostatic intraepithelial neoplasia (HPIN), incidentally discovered prostate carcinoma (IDPC) and prostate carcinoma (PC) . Each group included 20 specimens. The expression of LM and C Ⅳ in each group was examined with SP immunohistochemistry. Results The expression of LM was consistent with that of C Ⅳ. They surrounded prostate acinus and ductus with continuous linear and even distribution in NP, BPH and a majority of HPIN. LM and C Ⅳ unevenly distributed around prostate acinus and ducts. In a part of HPIN, they shown fragmental absence or interrupt distribution in IDPC and most absence in PC. Conclusions The results suggest that the expression of LM and C Ⅳ can help us to predict cancerization potential of HPIN, and discriminate benign and malignant prostate diseases.
出处
《诊断病理学杂志》
CSCD
2004年第3期148-149,i005,共3页
Chinese Journal of Diagnostic Pathology
