摘要
目的 :探讨川芎嗪在治疗急性冠状动脉综合征中的抗炎作用及其机制。方法 :32例急性冠状动脉综合征患者随机分入联合川芎嗪组和常规治疗对照组。两组患者均接受常规标准治疗 ;川芎嗪组患者加用川芎嗪注射液 3mg/ kg,1次 / 12 h静脉注射 ,连用 5 d,于给药前和给药 5 d后取血检测血浆 C反应蛋白 (CRP)、血清淀粉样蛋白 A(SAA)及纤溶酶原激活物抑制剂 1(PAI 1)浓度。结果 :与给药前比较 ,给药 5 d后对照组CRP和 SAA水平均显著增高 (P均 <0 .0 5 ) ,PCI 1轻度增高 ;而川芎嗪组 CRP水平无明显变化 ,SAA水平亦显著增高 (P<0 .0 5 ) ,PCI 1轻度降低 ;CRP、SAA及 PAI 1的绝对增加值川芎嗪组均显著低于对照组(P均 <0 .0 5 )。结论 :川芎嗪治疗急性冠状动脉综合征具有抗炎及促纤溶作用 ,此作用可能是川芎嗪能有效治疗心血管疾病的部分机制。
Objective: To investigate the anti-inflammatory effect and its mechanism of (tetrame-)(thylpyrazine(TMP)) in patients with acute coronary syndrome (ACS). Methods: Thirty-two patients were randomly divided into TMP group or routine treatment control group. All patients received the same standard treatment. The patients in TMP group received TMP 3 mg/kg intravenous injection every 12 hours for 5 days. Plasma concentrations of C-reactive protein (CRP), serum amyloid A (SAA) and plasminogen activator (inhibitor-1) (PAI-1) were measured at baseline and after 5 days of therapy. Results: After 5 days treatment, both concentrations of CRP and SAA increased significantly in control group (all P<0.05), PCI-1 increased mildly. In TMP group, only SAA had a significant increase (P<0.05), the change of CRP was not (significant), and the concentration of PCI-1 increased mildly. The absolute increases of CRP, SAA, and (PAI-1) were significantly less in TMP group than that in control group (all P<0.05). Conclusion: TMP has an anti-inflammatory and profibrinolytic effect in patients with ACS. These effects may contribute to the (clinical) benefits of TMP in ischemic heart disease.
出处
《中国中西医结合急救杂志》
CAS
2004年第4期196-198,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
国家"973"课题资助项目(G2000057004)
关键词
川芎嗪
急性冠状动脉综合征
炎症
tetramethylpyrazine
acute coronary syndrome
inflammation
