摘要
目的 研究乳腺癌组织中bcl 2和bax蛋白表达与乳腺癌钙化之间的关系。方法 5 4例乳腺癌 ,术前双侧乳腺钼靶X线摄影检查。术后应用免疫组化的方法检测乳腺癌组织细胞的bcl 2和bax蛋白表达。结果 钙化性乳腺癌 2 3例 ,非钙化性乳腺癌 3 1例。钙化性乳腺癌bcl 2蛋白高表达 2 1例 (91.3 % ) ;非钙化性乳腺癌高表达 2 0例 (64 .5 % ) ,两组间存在显著性差异 (P <0 .0 5 )。钙化性与非钙化性乳腺癌bax蛋白的高表达率分别为 60 .9%和 5 8.1% ,两组间无显著性差异 (P>0 .0 5 )。结论 钙化性乳腺癌组织细胞的bcl 2蛋白表达水平明显高于非钙化性乳腺癌 ,说明乳腺癌病变中钙化灶的出现与bcl
Objective To study the correlation between the expression of bcl-2 and bax protein and calcifications of breast cancer. Methods Mammography were performed in 54 cases with breast cancer. The expression of bcl-2 and bax protein were examined with immunohistochemical technique in breast cancer. Results Of 54 patients, 23 lesions were calcified, 31 were non-calcified. The high expression rate of bcl-2 protein was 91.3% (21 cases) in calcified breast cancer and was 64.5% (20 cases) in non-calcified breast cancer. There were obviously differential expression in two groups ( P <0.05). The high expression rate of bax protein was 60.9% in calcified breast cancer and was 58.1% in non-calcified breast cancer. There were no obviously differential expression in two groups ( P >0.05). Conclusion The bcl-2 expression was higher in calcified breast cancer than in non-calcified breast cancer. The relationship may be existed between calcifications and expression of bcl-2 protein in breast cancer.
出处
《中国医学影像技术》
CSCD
2004年第7期1103-1105,共3页
Chinese Journal of Medical Imaging Technology
