摘要
目的:阐明纵隔淋巴结转移(N2)的非小细胞肺癌(NSCLC)患者根治术后肿瘤复发的模式,为手术后采取针对性的辅助治疗提供依据。方法:回顾96例根治性切除术后病理诊断为N2肺癌患者的临床资料。术后2年内每6个月对患者进行随访复查,监测肿瘤复发情况。应用χ2检验比较手术后放疗及化疗对肿瘤复发模式的影响。结果:术后2年内肿瘤复发率为37.5%,复发模式以转移性复发为主(77.8%),多数为脑和肺转移(64.3%)。手术后放疗患者的局部复发率为5.2%,而未施行放疗患者的局部复发率为23.7%,两者比较有显著性差异(OR=5.69,P<0.05);手术后化疗者与未化疗者相比,局部复发和转移性复发的发生率的差别无显著性(P>0.05)。结论:转移性复发是N2非小细胞肺癌根治术后肿瘤复发的主要模式,手术后放疗可以减少N2肺癌根治术后肿瘤的局部复发。
Objective: To investigate the postoperative recurrence patterns in patients with resected stage Ⅲ (N2 disease) non-small cell lung carcinoma (NSCLC). Methods: Clinical data of ninety-six patients with NSCLC, who underwent radical surgery and were diagnosed to be with mediastinal lymph node metastasis (N2 disease) determined by histopathologic examination, were reviewed. Patients were followed up and checked up every six months for two years to detect recurrence lesion. The rate of local recurrence and distant metastasis within two years were calculated. The impact of postoperative adjuvant therapy on local recurrence and distant metastasis was compared by χ2 test. Results: Two-year recurrence rate was 37.5%. The main recurrence pattern was of distant metastasis (77.8%), and most patients were with brain and lung metastasis(64.3%). Local recurrence rate in patients with adjuvant radiotherapy was lower than that of patients without adjuvant radiotherapy (5.2% vs 23.7%, OR=5.69 P<0.05). There was no significant difference in local recurrence and metastatic recurrence of patients with and without adjuvant chemotherapy(P>0.05). Conclusion: Distant metastasis was main patterns of postoperative failure in patients with resected stage Ⅲ(N2 disease) NSCLC. Adjuvant radiotherapy could decrease local recurrence rate.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2004年第13期752-754,共3页
Chinese Journal of Clinical Oncology
