摘要
目的 探讨与评估富血小板血浆促进口腔种植骨缺损区骨组织再生的临床作用和效果。方法 口腔种植骨缺损病例共10例,男6例,女4例,平均年龄49.6岁;上颌窦提升植骨7例,种植体周围骨缺损植骨3例。病例分为2组,对照组6例,单纯植入骨替代品β相磷酸三钙,实验组4例,植入β相磷酸三钙与富血小板血浆混合物。术前、术后1周、3个月、6个月行X线检查;每组各有3例在术后4-6个月的二期手术中取得植骨标本,行组织学观察。结果 10例均未出现植骨感染,愈合良好。影像学观察显示植骨材料与周围骨组织结合良好。组织学观察可见各组中β相磷酸三钙颗粒为胶原纤维样组织或蓝染的新生骨组织包绕,无炎症细胞浸润表现。实验组与对照组相比,植骨颗粒周围包绕着较为稠密的蓝染组织,新形成的编织骨排列更为整齐有序,并可见大量蓝染组织侵入β相磷酸三钙颗粒微孔内部,颗粒吸收改建明显。结论 富血小板血浆具有促进口腔种植骨缺损区骨组织再生的作用。
Objective To evaluate the result of bone regeneration due to using PRP in combination with p-TCP in bone defect adjacent to oral implantation. Methods Ten patients ( 6 males, 4 females, with an average age of 49.6 years) participated in this study. Seven of them underwent maxillary sinus augmentations, and 3 underwent GBR for peri-implant bone defects. PRP + p-TCP was used in 4 cases and P-TCP in other 6 as control. X-ray examinations were carried out prior to operation and in 1 week, at 3 months, 6 months after operation. After 4-6 months ,3 biopsy specimens were obtained at the time of the second stage operation in each group. Results Bone grafts healed well without any infection in all cases. Radiographs showed that bone grafts integrated together with the bone. The histological result showed that new bone was formed among particles of β-TCP in both groups, but in PRP + p-TCP group denser and better arranged woven bone was observed, and more new bone was formed into the micropores of the particles. Conclusions The result in this study implied that PRP in combination with β-TCP can improve bone regeneration in bone defect adjacent to oral implantation.
出处
《中华口腔医学杂志》
CAS
CSCD
北大核心
2004年第4期269-272,共4页
Chinese Journal of Stomatology
关键词
富血小板血浆
口腔种植
骨再生
牙种植
骨缺损
Dental implantation
Bone regenration
Bone transplantation
Platelet-rich plasma
