摘要
目的 探讨有效治疗急性期脑缺血再灌注损伤的新药物。方法 采用线栓法制备大鼠大脑中动脉再灌注模型 ,将E 选择素溶于生理盐水后注入大鼠股静脉中 ,建立模型后 1h、4h和 1周断头取脑组织做病理切片及计算梗死体积。结果 E 选择素治疗组比对照组坏死体积明显减少。结论 E
Objective To explore a new drug to treat the injury of cerebral ischemia and reperfusion.Methods Local cerebral ischemic reperfusion model was made with thread embolism of left middle cerebral arter (MCA) of male SD rats. An artificial synthetic E selectin was dissolved in physiological saline and injected intravenuously in the model of SD rats.Cerebral infart volumes were calculated with computer tomography after one hour,four hours or a week.Results E selectin can effectively reduce infart volumes in brains after male SD rats ischemia and reperfusion.Conclusion An artificial synthetic E selectin can effectively protect brain after cerebral ischemia so as to treat local reperfusion injury.
出处
《中国血液流变学杂志》
CAS
2004年第2期181-182,193,共3页
Chinese Journal of Hemorheology
基金
江苏省卫生厅 13 5重点学科建设基金资助 (NO 苏人通 [1998] 5号 )
