摘要
目的 :观察重组人组织型纤溶酶原激活剂缺失变体 (reteplase ,Ret)对家兔纤溶和凝血系统活性的影响。方法 :采用常规方法测定家兔血液纤溶和凝血系统相关参数指标。结果 :Ret(3.75、7.5 0、15 .0MIU·kg-1)可明显降低纤溶酶原含量 ,使血浆纤维蛋白降解产物转呈阳性反应 ,缩短优球蛋白溶解时间 ,同时延长血浆凝血酶时间 ,凝血酶原时间及活化部分凝血活酶时间。结论
AIM: To investigate the effects of reteplase (Ret) on fibrinolytic and coagulation systems in rabbits. METHODS: The relative parameters of blood coagulation system and fibrinolytic systems were measured. RESULTS: Ret ( 3.75, 7.50, 15.0 MIU·kg -1) lessened the content of plasminogen (Plg) and promoted the plasma fibrinogen degradation product (FDP) significantly, shortened plasma euglobulin lysis time (ELT), prolonged plasma thrombin time (TT),prothrombin time (PT),and active partial thromboplastin time (APTT). CONCLUSION: Ret can promote fibrinolytic system function and inhibit blood coagulation system function.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2004年第7期778-780,共3页
Chinese Journal of Clinical Pharmacology and Therapeutics
