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补肾排毒合剂对慢性肾衰竭大鼠瘦素受体及神经肽Y在脑组织表达的影响 被引量:3

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摘要 目的 :探讨补肾排毒合剂改善慢性肾衰竭营养不良的作用机制。方法 :6 0例大鼠分为正常对照组、慢性肾衰竭组和肾衰竭补肾排毒合剂治疗组 ,并取大鼠脑组织 ,采用免疫组化技术 ,检测瘦素受体 (Ob -R)和神经肽Y(NPY)的蛋白表达。结果 :慢性肾衰竭后下丘脑组织Ob -R表达增强 ,NPY的表达降低 ;经补肾排毒合剂治疗后 ,下丘脑组织Ob -R的表达有所减少 ,NPY的表达有所恢复 (P <0 .0 5 )。结论 :补肾排毒合剂可能通过调节Ob -R及NPY的活性而改善慢性肾衰竭营养不良。
出处 《中国中西医结合肾病杂志》 2004年第7期410-411,共2页 Chinese Journal of Integrated Traditional and Western Nephrology
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参考文献7

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