摘要
目的 观察脑梗死急性期血清可溶性细胞间粘附分子 -1(SICAM -1)的含量变化 ,探讨其在脑梗死发生发展过程中的作用。 方法 采用酶联免疫吸附法(ELISA)检测55例急性期脑梗死患者 ,32例其他疾病对照组和30例正常健康对照组的SICAM -1含量。结果 (1)脑梗死患者SICAM -1含量较2对照组显著升高。(2)相关分析显示 :脑梗死时SICAM -1含量与外周血白细胞数呈正相关 ,与神经功能缺损评分呈负相关 ,而与血脂水平无明显相关关系。 (3)脑梗死患者SICAM -1含量与高血压史关系不密切 ,且SICAM -1含量与病灶大小无关。 结论 ICAM -1通过炎症机制参与了脑梗死的病理生理过程 ;急性期SICAM -1含量可以作为判断病情轻重的一个指标 ,脑梗死后应尽早使用抗ICAM
Objective To explore the changes and the clinical significance of the levels of serum soluble intercellular adhesion molecule-1(SICAM-1)in patients with acute cerebral infarction. Methods Serum levels of SICAM-1were detected in55patients with acute cerebral infarction(within2days),32patients suffering fromother neurologic diseases(20patients with sciatica,12patients with trigeminal neuralgia)and30healthy persons by using ELISA. Results 1)The serumlevels of SICAM-1of the patients with acute cerebral infarction were significantly higher than those of the control groups.2)The serum levels of SICAM-1were positively correlative with the number of leukocytes at acute stage,but were negatively correlative with the European stroke scale,and there was no significant correlation between the serum levels of SICAM-1and the serum levels of cholesterol and triglyceride.3)The serum levels of SICAM-1in the patients of cerebral infarction with or without hypertension had not significant difference.There was no obvious correlation between the levels of SICAM-1and the size of infarct lesion. Conclusion The serum levels of SICAM-1were significantly increased in the patients with acute cerebral infarction and SICAM-1maybe participated in the pathophysiologic process through inflammatory mechanism.The serum level of SICAM-1could become a reliable index to estimate the clinical severity and the anti-ICAM-1antibody should be used as early as possible after cerebral infarction.
出处
《浙江临床医学》
2004年第7期561-562,共2页
Zhejiang Clinical Medical Journal
