摘要
目的 :统计分析上海市徐汇区大华医院门急诊药物不良反应 (ADR)的发生情况。方法 :收集 2 0 0 2 0 8 0 1至2 0 0 3 12 31的门急诊ADR监测报告 110例 ,对年龄分布、ADR因果关系、严重程度分级、ADR转归、药物情况及ADR临床表现等进行统计。 结果 :病人年龄分布广泛 (2～ 92 )岁 ;ADR肯定 17例 ,很可能的 5 8例 ,可能 31例 ;ADR重度占 2 0 91% ,中度占77 2 7% ;治愈好转率为 10 0 %。抗菌药物的ADR发生率为 77.2 7% ,中药制剂 14 .5 5 % ,其他 8 18%。ADR临床表现以皮肤及其附件最常见 (4 8.84 % ) ,血液系统最严重 (3.1% )。 结论 :我院门急诊的ADR中老年人发生最多 ;发生ADR最多的是抗菌药物 ,其中以头孢菌素类占首位 ;ADR临床表现以皮肤及其附件的不良反应为主 ;处方时需注意合理用药。
Objective: To investigate the situation of adverse drug reaction (ADR) of patients in emergency and outpatient departments. Methods: One hundred and ten ADR reports from 2002-08-01 to 2003-12-31 were collected and analyzed. The analyses included the distribution of age, the causes and results of ADR, degrees of ADR, recovery, frequency of ADR and the clinical manifestations. Results: The distribution of age was from 2 to 92 years old. There were 17 affirmative,58 very probable and 31 possible ADR reports. The incidence of severe ADR was 20.91% and the moderate was 77.27%. Rate of recovery was 100%. The incidence of ADR of antimicrobials was the highest (77.27%),the preparations of Chinese materia medica ranked second (14.55%),and the others accounted for 8.18%.The incidence of skin ADR was common(48.84%). The most severe cases of ADR occurred in blood system (3.1%). Conclusion: The ADR occurs most frequently in the aged patients. The most frequent causes of ADR are antimicrobials. Cephalosporins rank first. The skin injuries are the most frequent ADR. The reasonable drug use should be considered when prescriptions are made.
出处
《药学服务与研究》
CAS
CSCD
2004年第2期170-172,共3页
Pharmaceutical Care and Research
关键词
门急诊
药物
不良反应
分析
emergency and outpatient departments
adverse drug reactions
analysis
