摘要
目的 分析睾丸原发性非霍奇金淋巴瘤 (PNHL)的临床特点及病理特征 ,探讨复发部位对预后的影响及可能的转移方式。方法 对 2例睾丸PNHL进行HE及免疫组化染色 ,结合文献对其临床病理特征及随访资料进行分析。结果 患者年龄为 82岁、6 7岁 ,均为单侧睾丸肿大伴有疼痛 ,免疫表型瘤细胞表达CD4 5、CD4 5RA、CD2 0 ,病理诊断为弥漫大B细胞性淋巴瘤 ,中心母细胞性 ,临床Ⅰ期。病例 1单纯患侧睾丸切除术后第 5个月出现鼻咽部复发 ,病例 2双侧睾丸切除术后化疗于第 6个月先后出现腹膜后淋巴结、肝、肾、肺累及 ,第 10个月出现胸水 ,第 16个月死亡。结论 睾丸PNHL有很高的结外复发倾向 。
Purpose To investigate the clinical and pathologic features of primary testicular non-Hodgkin’s lymphoma (PNHL) in testis and to describe the outcome with special attention to locations and patterns of recurrence. Methods Two cases of primary testicular lymphoma were studied by HE staining and immunohistochemistry, and their clinicopathological characteristics were analysed. Results The patients were 82 and 67 years old and first seen with an enlarging painful testicular mass. The results of immunohistochemistry showed that all cases were positive for CD45, CD45RA and CD20. The patients were diagnosed as diffuse large B cell lymphomas (DLBCL), stage I. One patient received orchiectomy alone and relapsed in the nasopharynx after 5 months. The other one was treated with chemotherapy after orchiectomy and experienced relapse in multiple extranodal sites after a disease-free interval of 6 months and died of disease in 16 months. Conclusions Primary testicular lymphoma is associated with a high incidence of extranodal recurrence and an unfavorable outcome.
出处
《临床与实验病理学杂志》
CAS
CSCD
2004年第3期328-331,共4页
Chinese Journal of Clinical and Experimental Pathology
