摘要
目的 :观察ACEI加安体舒通对心脏胶原更新和左室重量的影响。方法 :临床研究随机入选原发性高血压患者 135人 ,随机分入A(ACEI+安体舒通 )、B(ACEI)、C (非RAAS干预治疗 )三组 ,同等控制血压 ,观察 1年 ,比较 3种治疗方案对心肌胶原更新和左室重量的影响。结果 :临床研究显示在同等控制血压的前提下 ,减低血清PⅢNP的疗效及减低左室重量指数 ,ACEI联合抗醛固酮治疗优于单纯ACEI治疗 ,优于非RAAS干预治疗。结论 :原发性高血压患者应用ACEI联合抗醛固酮治疗比单纯ACEI治疗更好的减低血清PⅢNP和左室重量指数 ,并使心肌间质胶原沉积明显减低 。
Objective:To observe the effects on collagen turnover and the relationship between PⅢNP and remedy,PⅢNP and left ventricular remodeling by controlling the angiotensin II and aldosteron of RAAS under the premise of controlling blood pressure stably and efficiently. Methods: 135 patients with hypertension were observed for one year. All of them were divided into three groups randomly,including A (ACEI+spironolactone), B (ACEI) and C (traditional remedy: intervention with routine therapeutics excluding the drugs effecting on RAAS) groups. The serum PⅢNP and the left ventricular weight index (LVWI) were compared before and after the therapy. Results:Under the same blood pressure controlling precondition,the remedy of a low dose of spironolactone along with ACEI can decrease serum PⅢNP and LVWI much more. The remedy of ACEI with a low dose of spironolactone is correlated with the decrease of serum PⅢNP and LVWI. Conclusion:The remedy of a low dose of spironolactone along with ACEI is better in the decreasing of serum PⅢNP,the myocardial interstitial collagen deposition,and the left ventricular remodeling than ACEI remedy and traditional remedy. This effect is independent on blood pressure control.
出处
《军医进修学院学报》
CAS
2004年第3期164-166,共3页
Academic Journal of Pla Postgraduate Medical School
基金
"十五"军队科研基金资助项目 (0 1Q0 5 6)
关键词
ACEI
小剂量
安体舒通
左室重构
胶原更新
原发性高血压
心肌肥厚
aldosterone
fibrosis,myocardium
collagen
PⅢNP(three type procollagen amino terminal peptide)
left ventricular weight index (LVWI)
