摘要
麻醉猫20只,随机分3组,失血性休克组(n=8);电刺激PVH组(n=6);失血性休克加电刺激PVH组(n=6)。分别观察3组不同时程血浆AVP含量的变化。结果3组血浆AVP含量均在5 min内达到峰值,分别为336.3±62.2 pg/ml(P<0.01);285.7±59.4 pg/ml(P<0.01);605.1±93.3 pg/ml(P<0.01)。表明失血和电刺激PVH中枢均能引起血浆AVP含量明显升高,两者同时刺激对血浆AVP含量呈现叠加效应。提示,重度失血性休克早期,当低血压持续存在时,PVH-垂体系统功能并未受到明显损伤,且仍能保持其活性,继续参与血浆中AVP含量的调节。
Twenty cats were anesthetized and divided randomly into 3 groups: hemorrhagic shock (HS), electrical stimulation of the hypothalamic paraventricular nucleus (ESPVH) and hemorrhagic shock with addition to electrical stimulation of PVH (HS+ESPVH), so as to observe the change of plasma AVP during experimental period. The results showed that plasma AVP was increased to peak in the initial 5 min in all 3 group animals, and their values were 336.3±62.2 pg/ml (P<0.01), 285. 7±59. 4 pg/ml (P<0. 01) and 605. 1±93. 3 pg/ml (P<0. 01) respectively,. and that either hemorrhagic shock stimulation or central electrical stimulation of PVH may cause release of AVP. When the two stimulations were given simultaneously, the increase of plasma AVP revealed a summation effect. The experimental results suggest that at the initial stage of hemorrhagic shock, though being in the continuing hypotensive state, the function of PVH was not injured significantly, its activity was maintained and still participated in the regulation of plasma AVP.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1993年第4期335-338,共4页
Academic Journal of Second Military Medical University
关键词
休克
出血性
精氨酸升压素
下丘脑
shock, hemorrhagic
argipressin
paraventncular hypothalamic nucleus
animal
cats
