摘要
测定了BALB/c鼠柯萨奇B_3病毒(Cox B_3)心肌炎病理过程中脾NK细胞活性及血清、心肌组织匀浆中干扰素水平。在感染后的第3天,NK细胞活性及血清、心肌组织匀浆中干扰素滴度达高峰,并以较高水平维持到第7天。小鼠受染后3～7d心肌组织中病毒滴度亦达峰值。随着病毒从心肌中消失,NK细胞活性及干扰素滴度急剧降至对照组水平。实验结果提示:鼠Cox B_3感染早期,体内NK细胞活性和干扰素滴度升高的主要作用是溶解病毒感染细胞、限制病毒复制。
The level of interferon (IFN) in serum and homogenized cardiac tissue, and the activity of natural killer cells in Coxsackievirus B3 induced myocarditis in BALB/c mice were determined. NK cell cytolytic activity and IFN titers peaked on day 3~ 7 postinoculation (p.i.) and then declined. Virus titers in heart tissue reached a maximum on day 7 p.i. and then declined. These results suggest that the increase of NK cell activity and IFN titers provides some protection against Cox B, induced myocarditis by limiting virus replication in heart tissue.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1993年第4期344-347,共4页
Academic Journal of Second Military Medical University
关键词
柯萨奇病毒B
心肌炎
杀伤细胞
Coxsackie B viruses
myocarditis
interferon
killer cell, natural
animal
mice
