摘要
目的 :制备痹痛宁贴剂 (洋金花、麝香、樟脑等 )并研究其体外释药性能和透皮吸收行为。方法 :以水溶性高分子材料为基质制备痹痛宁贴剂 ,采用高效毛细管电泳法测定制剂中东莨菪碱的含量。按中国药典方法进行了体外释放度的测定 ,利用Franz扩散池研究了贴剂的透皮吸收行为。结果 :制备的痹痛宁贴剂含量稳定 ,体外释药符合Higuchi方程 ,释放速率为 0 .4 6 98mg·cm-2 ·h-1/ 2 。其透皮吸收为零级动力学过程 ,渗透速率为 0 .0 6 7mg·cm-2 ·h-1。结论 :痹痛宁贴剂为皮肤控释型透皮给药系统。
AIM: To prepare Bitongning Patch(Flos Daturae, Moschus and Camphora, etc.) and study its in vitro release characteristics. METHODS: Bitongning Patch was prepared with high polymer hydrophilic material as matrix. The determination method of scopolamine was established by HPCE. The in vitro release was studied according to the requirement of Chinese Pharmacopoeia(2000) and the percutaneous absorption of Bitongning Patch was evaluated in use of the Franz diffusion cell. RESULTS: The release mechanism of Bitongning Patch in vitro coincided with Higuchi Equation. The release rate was 0.4698mg·cm -2·h -1/2. Scopolamine in Patch permeated in vitro at the speed of 0.067mg·cm -2·h -1 by zero-order kinetics. CONCLUSIONS: Bitongning Patch is a skeleton controlled TDDS whose permeation speed is limited by skin.
出处
《中成药》
CAS
CSCD
北大核心
2004年第6期437-439,共3页
Chinese Traditional Patent Medicine
