摘要
目的:观察维胺酯胶囊和全反式维A酸霜(商品名:迪维霜)治疗寻常痤疮的疗效。方法:将寻常痤疮患者随机分成3组,A组口服维胺酯胶囊,外用0.025%迪维霜;B组外用0.025%迪维霜;C组口服多西环素(商品名:强力霉素),外用硫磺炉甘石洗剂。均各治疗6周。结果:A组对丘疹和脂溢的疗效优于B组和C组(P<0.05),对粉刺的疗效优于C组(P<0.001),对脓疱的疗效优于B组(P<0.05),对结节囊肿的疗效3组差异无显著性;综合疗效A组优于B组和C组(P<0.05);A组中中度痤疮患者的效果优于B组和C组(P<0.05),但对轻度痤疮3组差异无显著性。结论:口服维胺酯胶囊联合外用迪维霜治疗轻、中度痤疮疗效较好。
Objective: To investigate the clinical effect of oral viaminate and tretinoin cream in acne. Methods: One hundred and twenty patients with acne were divided into three groups at random: Group A was treated by oral viaminate and topical tretinoin cream; Group B by topical tretinoin cream; Group C by oral doxycycline and topical sulfur calamine lotions. The treatment lasted for 6 weeks. Results: The therapeutic effect of Group A was significantly higher in papules and seborrhea than that of Group B and Group C(P < 0.05); in comedones than that of Group C(P < 0.001); in pustules than that of Group B(P < 0.05). There was no marked difference in nodules and cysts of 3 groups. The global effect of Group A was better than that of other groups(P < 0.05). The clinical effect of Group A was higher than other groups in moderate acne(P < 0.05), while the effect of 3 groups was not significantly different in mild acne. Conclusion: Oral viaminate and topical tretinoin cream have significantly therapeutic effect on mild to moderate acne.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2004年第7期439-440,共2页
Journal of Clinical Dermatology
