摘要
以苯甲醚为起始原料,与乙酰氯发生付-克酰基化后脱甲基得到4-羟基苯乙酮,然后与液溴进行α-溴代得到2-溴-1-(4-羟苯基)乙酮,再与叔丁胺进行胺化得到1-(4-羟基苯基)-2-(叔丁基氨基)乙酮,最后用氢硼化钠还原合成目标产物1-(4-羟基苯基)-2-(叔丁基氨基)乙醇,总收率约为42.3%。
1-( 4-hydroxyphenyl)-2-( tert-butylamino) ethanol( Synephrine derivative) was synthesized from the following process: 4-hydroxyacetophenone was prepared using anisole as the raw material by Friedel-Crafts acylation with acetyl chloride followed by demethylation,and was α-brominated with liquid bromine to get 2-bromine-1-( 4-hydroxyphenyl) ethanone,then was ammoniated with tert-butylamine and reduced with sodium borohydride with a total yield of about 42. 3%.
出处
《化学通报》
CAS
CSCD
北大核心
2015年第6期569-571,共3页
Chemistry
基金
吉林省教育厅计划科研项目(吉教科合字2012106)资助
