摘要
目的分析注意缺陷/多动障碍(ADHD)儿童青少年超重肥胖的发生率及其与正常人群的差异。方法检索万方、维普、中国知网(CNKI)、中国生物医学文献数据库(CBM)、Pub Med、ISI Web of Knowledge、Medline数据库,设定纳入标准,对纳入文献采用美国卫生保健质量和研究机构(AHRQ)推荐的横断面研究质量评价标准进行评估,采用Rev-Man 5.1进行结果分析。结果以超重人数为结局指标:I2=87%,OR=2.00,95%CI 1.05~3.83,P=0.04,儿童青少年ADHD患者的超重率明显高于正常儿童青少年人群。以肥胖人数为结局指标,对纳入的10篇文献定量汇总:I2=87%,OR=1.69,95%CI 1.00~2.84,P=0.05,患有ADHD的儿童青少年人群的肥胖率与正常人群的差异无统计学意义。以肥胖超重人数为结局指标,以ADHD不同亚型为界点进行亚组分析,在多动/冲动为主型亚型中,ADHD组的肥胖和超重率与正常组间的差异无统计学意义(I2=9%,OR=0.95,95%CI 0.58~1.57,P=0.85);在注意障碍为主型和混合型亚型中,两组肥胖超重率差异有统计学意义(OR=2.28,95%CI 1.67~3.12,P【0.000 01;OR=1.71,95%CI 1.21~2.41,P=0.002)。结论 ADHD儿童青少年的超重率高于正常人群,两者肥胖率差异无统计学意义。注意障碍为主型和混合型ADHD患者的超重肥胖率、男性ADHD患者的超重率、总体人群中抽取的ADHD患者的超重率高于无ADHD的正常人群。
Objective To analyse the prevalence of overweight and obesity in children and adolescents with attention-deficit hyperactivity disorder, and investigate its difference with normal individuals. Methods The database of Wanfang, VIP, CNKI, CBM, Pub Med, ISI Web of Knowledge and Medline were utilized to search the literature with the established criteria. The included literature was evaluated by the cross-section study quality assessment criteria recommended by Agency for Healthcare Research and Quality(AHRQ), and was analysed with Rev-Man 5.1 software.Results With the number of overweight as an outcome indicator, I2= 87%, OR = 2.00, 95% CI 1.05- 3.83, P =0.04, and the prevalence of overweight in children and adolescents with ADHD was higher than that in normal ones.With the number of obesity as an outcome indicator and quantitative analysis of the 10 included literature, I2= 87%,OR = 1.69, 95%CI 1.00- 2.84, P = 0.05, and there was no significant difference in the prevalence of obesity between children and adolescents with ADHD and normal individuals. With the number of obesity and overweight as outcome indicator and stratification by different ADHD types, there was no significant difference in the prevalence of obesity and overweight between children and adolescents with ADHD of hyperactivity/impulsion type and normal individuals(I2= 9%,OR = 0.95, 95% CI 0.58- 1.57, P = 0.85), and there were significant differences in the prevalence of obesity and overweight between children and adolescents with ADHD of attention disorder type and combination type and normal individuals(OR = 2.28, 95%CI 1.67- 3.12, P < 0.000 01; OR = 1.71, 95%CI 1.21- 2.41, P = 0.002). Conclusion The prevalence of overweight in children and adolescents with ADHD is higher than that in normal individuals, while there is no significant difference in the prevalence of obesity between them. The prevalence of overweight and obesity in ADHD of attention disorder type and combination type, the prevalence of overweight in male ADHD patients and that of ADHD
出处
《教育生物学杂志》
2014年第4期224-231,共8页
Journal of Bio-education
关键词
注意缺陷/多动障碍
肥胖
超重
META分析
儿童
青少年
attention-deficit hyperactivity disorder
obesity
overweight
Meta analysis
child
adolescent
