Role of poly(ADP-ribose) polymerase 1 in DNA methylation changes induced by hydroquinone in human bronchial epithelial cell

Role of poly(ADP-ribose) polymerase 1 in DNA methylation changes induced by hydroquinone in human bronchial epithelial cell

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摘要 Objective To investigate the DNA methylation changes induced by hydroquinone(HQ)in human bronchial epithelial cells and to explore the role of poly(ADP-ribose)polymerase-1(PARP-1)in this process.Methods Human bronchial epithelial 16HBE cells and PARP-1-deficient 16HBE cells(16HBE-shPARP-1 cells)were exposed to HQ(10,20,40,60,and 80μmol/L)for

作者沙炎

机构地区 Shenzhen Occu Dis Prev & Treat Center

出处《China Medical Abstracts(Internal Medicine)》 2014年第2期78-79,共2页 中国医学文摘（内科学分册（英文版）

关键词 BRONCHIAL methylation RIBOSE DNA PARP exposed deficient genomic capillary PRESSION

分类号 R346 [医药卫生—基础医学]

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Role of poly(ADP-ribose) polymerase 1 in DNA methylation changes induced by hydroquinone in human bronchial epithelial cell

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