摘要
目的探讨阿托伐他汀对2型糖尿病老年患者颈部动脉斑块的影响。方法 2型糖尿病老年患者50例为研究对象,将所有患者按照随机对照的原则分为治疗组(25例)和对照组(25例),对照组患者入院后常规控制血糖在正常范围。治疗组在此基础上还服用阿托伐他汀片。观察两组治疗前后TC、TG、LDL-C、HDL-C、血管斑块大小及颈内动脉内膜中层厚度变化情况。结果与对照组比较,治疗组TC、TG、LDL-C减低更明显,HDL-C升高更明显,其差异均有统计学意义(P<0.05)。治疗组斑块大小和颈内动脉内膜中层厚度较对照组减低更明显,其差异均有统计学意义(P<0.05)。结论阿托伐他汀能明显缩小2型糖尿病老年患者颈部动脉斑块大小,值得临床应用。
Objective To investigate the effect of atorvastatin on plaque formation of carotid arteries in elderly patients with type 2diabetes. Methods Fifty elderly patients with type 2 diabetes from 2010 February to 2012 October in our hospital were selected as the object of study. All patients were randomly divided into treatment group(25 cases) and control group(25 cases). Blood sugar in control group was controlled in normal range. The treatment group,on this basis,used oral atorvastatin. The changes of TC,TG,LDL- C,HDL- C,vascular plaque size and internal carotid artery intima- media thickness in the two groups were observed before and after treatment. Results Compared with the control group,TC,TG and LDL- C in treatment group decreased significantly,and HDL- C in treatment group increased obviously,and the differences were statistically significant( P < 0. 05). Compared with control group,the patch size and CIMT in treatment group decreased more significantly,and the differences were statistically significant( P < 0. 05). Conclusion Atorvastatin can significantly reduce carotid artery plaque size in elderly patients with type 2 diabetes,which is worth clinical using.
出处
《安徽医学》
2013年第10期1529-1531,共3页
Anhui Medical Journal
关键词
阿托伐他汀
糖尿病
动脉斑块
颈部
Atorvastatin
Diabetes
Arteriosclerosis of carotid arteries
