摘要
目的：观察神经节苷脂（GM1）对脑梗死急性期认知功能障碍的改善作用，评估其临床疗效和安全性。方法选择2009年1月至2013年1月上海市第一人民医院宝山分院收治的41例脑梗死急性期认知功能障碍患者，随机分为观察组20例，对照组21例，所有病例均采用神经内科急性脑梗死常规治疗方案，观察组在此基础上加用 GM1治疗。治疗前后行简易智能精神状态检查量表(MMSE)，观察认知功能的改善程度。结果两组病例治疗后 MMSE 评分较治疗前均明显好转(P<0.05)，但观察组改善更为明显。观察组治疗后与对照组治疗后 MMSE 评分比较差异有统计学意义。结论在急性脑梗死常规治疗基础上，应用 GM1能明显改善急性脑梗死患者的认知功能障碍及生活质量。
Objective Inordertoinvestigatethefunctionofganglioside(GM1)onacutephasein cerebral infarction of cognitive impairment, to evaluate the clinical efficacy and safety, we will carry out the following experiment. Methods In a sample of 41 groups on acute phase in cerebral infarction of cognitive impairment , we divide it randomly into two large groups, one for observation group which includes 20 cases, the other is control group, including 21 cases. All patients were treated with conventional treatment of acute cerebral infarction neurology program. On the basis of conventional treatment, GM1 treatment is also used in the observation group. With the help of intelligent Mental State Examination (MMSE) before and after the treatment, we can observe the improvement of cognitive functions. Results After treatment, two large groups on the score of MMSE were both improved compared with without treatment (P<0.05). However, observation group improved more in the comparison of control group. There is statistical significance on difference between observation group and control group in terms of MMSE score after treatment. Conclusion On the basis of conventional treatment of acute cerebral infarction, applying GM1 can apparently improve both cognitive impairment and life quality of patients with acute cerebral infarction.
出处
《中国临床实用医学》
2014年第3期39-40,共2页
China Clinical Practical Medicine
关键词
脑梗死
急性期
认知功能
神经节苷脂
Cerebral infarction
Acute phase
Cognitive functions
Ganglioside
